ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 3 (1), pp. 001-005, January, 2012. © International Scholars Journals
Full Length Research Paper
Isolation, characterization and antibacterial activity of alkaloid from Datura metel Linn leaves
Donatus Ebere Okwu* and Ephraim Chintua Igara
Department of Chemistry, Michael Okpara University of Agriculture, Umudike P.M.B. 7267 Umuahia, Abia State, Nigeria.
Accepted 16 November, 2011
Abstract
A new antibacterial agent 51, 71 dimethyl 61– hydroxy 31, phenyl 3 a - amine b - yne sitosterol 1 has been isolated from Datura metel leaves. The structure of 1 was established using 13C, 1H NMR, IR and MS spectroscopic data. Compound 1 displayed antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabis, Solmonella typhi, Bacillus subtilis and Klebsiella pneumonia but could not inhibit Escherichia coli. This result supported the use of Datura metel in phytomedicine for the treatment of asthma, cough, burns and healing of wounds in Nigeria.
Key words: Datura metel, sterol alkaloid, antibacterial agent, phytomedicine.