ISSN 2756-3375
African Journal of Immunology Research ISSN 9431-5833 Vol. 6 (1), pp. 001-006, January, 2019. © International Scholars Journals
Full Length Research Paper
Benign monoclonal gammopathy in a dog exhibiting a low antibody titer to EHRLICHIA CANIS
Stephanie Ng1, Sophia Lim1, Allison Daub2, Surinder S. Saini1 and Azad K. Kaushik1,3*
1Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada N1G 2W1, Canada.
2Campus Estates Animal Hospital, Guelph, Ontario, Canada N1G 3A2, Canada.
3Department of Molecular and Cell Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1, Canada.
Accepted 03 September, 2018
Abstract
The occurrence of a remarkable benign γ-monoclonal gammopathy in a 2.5-year-old intact male bichon frise dog, secondary to acute EHRLICHIA CANIS infection, with no travel history outside of Ontario. Exceptionally high levels of serum IgG (104.0 g/ L) as a result of benign monoclonal gammopathy were noted during the disease state that returned to normal subsequent to recovery. Treatment with doxycyline and prednisone resulted in complete recovery and disappearance of the monoclonal gammopathy. In conclusion, such a recovery from monoclonal gammopathy due to infection is indeed promising since very high serum IgG concentrations can be brought back to physiological levels by therapeutic intervention.
Key words: Dog, benign monoclonal gammopathy, Ehrlichia canis.