ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 3 (7), pp. 001-004, July, 2012. © International Scholars Journals
Full Length Research Paper
Phytochemical and pharmacological evaluation of Solanum nigrum Linn.
V. Ravi2*, T. S. M. Saleem2, P. P. Maiti2, K. Gauthaman2 and J. Ramamurthy1
1Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Madurai, TN, India.
2Department of Pharmacology, Himalayan Pharmacy Institute, Majhitar, East Sikkim-737136, India.
Accepted 17 April, 2012
Abstract
The present investigation designed to evaluate the phytochemical and pharmacological activity of ethanolic extract of Solanum nigrum in experimental animal models. The ethanolic extract of S. nigrum was used in three different doses (100, 200 and 300 mg/kg bw) to evaluating anti- inflammatory and anti-convulsant activity by employing carrageenan paw edema and Supramaximal electric shock (MES) methods. Ethanolic extract of S. nigrum produced significant anti-inflammatory (P < 0.01) and anti-convulsant (P < 0.05) effect in dose dependent manner. The flavonoids present in the berries might be a responsible active constituent for this activity.
Key words: Solanum nigrum, anti-inflammatory activity, anti-convulsant, flavonoids.