ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 4 (4), pp. 001-005, April, 2013. © International Scholars Journals
Full Length Research Paper
Salivary nicotine and cotinine concentrations in unstimulated and stimulated saliva
N. Robson1*, A. J Bond2 and K. Wolff2
1University Malaya, Department of Primary Care Medicine, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia.
2King’s College London, Institute of Psychiatry, London SE5 8AF, United Kingdom.
Accepted 12 January, 2013
Abstract
Salivary nicotine and salivary cotinine is widely used in clinical and epidemiological studies to validate smoking cessation. However, the reported collection for salivary nicotine and salivary cotinine vary by technique and duration. This study investigated the influence of salivary collection by unstimulation and stimulation technique of the concentration of salivary nicotine and salivary cotinine. It was found that unstimulated technique produced the highest salivary nicotine concentration, whereas stimulated technique produced the highest salivary cotinine concentration. The results of this study suggest that it is important to standardise salivary nicotine and cotinine collection technique.
Key words: Saliva, smoker, nicotine, cotinine, technique, biological marker, oral, verify, passive, tobacco, smoke.