ISSN 2756-3413
African Journal of Virology Research ISSN 2756-3413 Vol. 20 (1), pp. 001-003, January, 2026. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Short Communication
Inhibition of Yeast Proliferation and Pathogenesis by Non-Steroidal Anti-Inflammatory Drugs
Desmond M. Ncango1, Carolina H. Pohl1, Pieter W. J. van Wyk2 and Johan L. F. Kock1*
1UNESCO MIRCEN, Department of Microbial, Biochemical and Food Biotechnology, University of the Free State,
P. O. Box 339, Bloemfontein, 9301, South Africa.
2Centre for Microscopy, University of the Free State, P. O. Box 339, Bloemfontein, 9301, South Africa.
Accepted 10 November, 2025
Studies on yeasts exposed non-steroidal anti-inflammatory drugs (NSAIDs) such as acetylsalicylic acid (aspirin) as potential anti-mitochondrial antifungals. In this study, various NSAIDs were tested for antifungal activity on the human yeast pathogens Candida albicans and Cryptococcus neoformans. Our results suggest a dual action for these drugs, that is, antifungal as well as anti-inflammatory. These results could be useful in the treatment of fungal infections.
Key words: Acetylsalicylic acid, antifungal, anti-inflammatory drugs, anti-mitochondrial, Candida albicans, Cryptococcus neoformans, Eremothecium ashbyi.