ISSN 2326-7283
African Journal of Internal Medicine ISSN: 2326-7283 Vol. 3 (8), pp. 177-179, September, 2015. © International Scholars Journals
Case Report
Warfarin induced skin necrosis related with high prevalence of morbidity and mortality
*Nassan Yadav, Nujoom Al Jaziri and Hamdam Al-Shaikh
Department of Internal Medicine, Faculty of Medicine, Al Ghurair University, United Arab Emirates.
E-mail: nas.yadav@yahoo.com
Accepted 15 August, 2015
Abstract
Warfarin induced skin necrosis (WISN) represents a rare complication of warfarin therapy that is associated with high incidence of morbidity and mortality. It usually presents in susceptible patients within 10 days of initiation of therapy. The study report a case of 24 years old gentleman who is known to have a unique rare inborn error of metabolism (primary hyperoxaluria), and was diagnosed with late onset WISN after being on warfarin for 28 months for recurrent pulmonary embolisms. The skin lesions in the study patient were not associated with underlying protein C or S deficiency.
Key words: Warfarin induced skin necrosis, primary hyperoxaluria (PH), calciphylaxis, end stage renal disease (ESRD).