ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 4 (2), pp. 001-003, February, 2013. © International Scholars Journals
Short Communication
Analgesic and anti-inflammatory activity of aqueous root extract of Cassia sieberiana D. C. (Caesalpiniaceae)
Guata Yoro Sy1*, Alioune Dior Fall2, William Diatta2, Malick Gueye2, Khady Badji2, Emmanuel Bassène2 and Babacar Faye1
1Laboratoire de Pharmacologie, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Université Cheikh Anta Diop de Dakar, BP 5005, Dakar-Sénégal.
2Laboratoire de Pharmacognosie et Botanique, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Université Cheikh Anta Diop de Dakar, BP 5005, Dakar-Sénégal.
Accepted 19 November, 2012
Abstract
The analgesic and anti-inflammatory activity of Cassia sieberiana roots were investigated. Analgesic activity had been investigated using acetic acid induced contortions in mice. The aqueous root extract of C. sieberiana at 300 mg/kg per os showed similar analgesic activity than 100 mg/kg of acetylsalicylic acid (20 ± 1.14 vs 26 ± 1.79 contortions) (ns, p < 0.05). In rat paw oedema model, C. sieberiana aqueous root extract significantly decreased carrageenan-induced oedema. These results showed that aqueous root extract of C. sieberiana possessed both analgesic and anti-inflammatory activities, which have justified their use in Senegal traditional medicine to treat pain and inflammation.
Key words: Cassia sieberiana, pain, inflammation, phytotherapy.