ISSN 2326-7275
International Journal of Anatomy and Physiology ISSN: 2326-7275 Vol. 8 (11), pp. 001-007, November, 2019. © International Scholars Journals
Full Length Research Paper
Immune stimulating activity of water-soluble polysaccharide fractions from Dendrobium nobile Lindl.
Aoxue Luo and Yijun Fan*
Department of Landscape Plants, Sichuan Agriculture University, Chengdu 611130, China.
Accepted 21 April, 2019
Abstract
Four water-soluble polysaccharides (DNP1-1, DNP2-1, DNP3-1 and DNP4-2) were obtained from the aqueous extracts of the stems of Dendrobium nobile Lindl. by hot water extraction, ethanol precipitation, and fractionated by DEAE-cellulose ion exchange chromatography and Sephadex G-200 gel filtration chromatography. The evaluation of tumor inhibition and immunomodulatory activity suggested that DNP4-2 could significantly increase the immune index, and strongly promote the secretion of IL-2, TNF-α and IFN-γ, and also decrease the concentrations of MDA in blood serum. DNP4-2 should be explored as a potential anti-tumor drug.
Key words: Dendrobium nobile Lindl., immune stimulating, polysaccharide.